MD Prescriptives’™ NanoZeolite MD™ is made from a water suspension of natural food-grade zeolite which is sourced from uncontaminated clinoptilolite clay. More specifically, the primary bioactive ingredient found in NanoZeolite MD™ is composed of a silicate mineral complex featuring particle sizes with superior absorption high-surface energy over common food-grade zeolite products. The particle size range spans the upper nanometer to lower micrometer size ranges, which 'defines' the absorption powers (sorption capacity or biosorption performance) of the “micronized” zeolite particles as 'highly bioactive'.1,2 These highly bioactive micronized zeolite particles efficiently promote removal of noxious body loads containing harmful chemicals (i.e., xenobiotic elimination), heavy metals (i.e., chelation), radionuclides (i.e., decorporation), exoprotein elimination, and even supports microbiota purification.3,4 *
Safety and Efficacy
Zeolite is listed under the FDA’s G.R.A.S. list.5 Zeolite possesses powerful cation-exchange physics, making it ideal to grab onto (i.e., chelate) noxious cations.6 It has long been safely used as a feed additive for livestock to boost their health when confronting select health challenges.7 It is important that the clinoptilolite raw source material is tested for heavy metal contaminants prior to being manufactured into a nutraceutical product intended to promote xenobiotic elimination and decorporation in your patients.8*
Promotes Detoxication
At the end of this discussion, we present two compelling unpublished clinical results conducted at a certified laboratory illustrating the amazing ability of the primary ingredient in NanoZeolite MD™ to promote highly cost-effective xenobiotic elimination and decorporation in your patients when administered in the proper dosages.
Bioactive zeolite promotes immune functions in immunodeficiency states.60,61 One key function bioactive zeolite is known for, is its ability to promote beneficial levels of antioxidants in the blood stream.62
Hall JB, Dobrovolskaia MA, Patri AK, McNeil SE. Characterization of Nanoparticles for Therapeutics. Nanomedicine (Lond). 2007 Dec;2(6):789-803.
Horiba Particle Size Distribution Analyzer LA-950 V2; Project No.: 009-1144. ID# 201605261039963. Assay No.: E261/16. Hazen Refractive Index - Operator: A. Cavendor. Smallest zeolite particles detected were ≤877 nanometers (≤0.877µm) in diameter. Median particle size range ~10.80 micrometers. Hazen Research, Inc. May 5th, 2016.
Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota.... PLoS One 2016 Apr 26;11(4):e0154061.
Hrenovic J, et al. J Hazard Mater. 2010 Nov 15:183(1-3):655-63.
U.S. Food & Drug Administration. Database of Select Committee on GRAS Substances (SCOGS) Reviews. Report No.: 61; ID Code: 73987-94-7; CFR Section: 182.2727; Year – 1979.
Papaioannou D., Katsoulos P. D., Panousis N., Karatzias H. The role of natural and synthetic zeolites as feed additives.... Microporous Mesoporous Mater. 2005;84:161–70.
Tao YF, Fang SY, Liu ZY, Wang Y, Zhu JH. Trapping the Lead Ion in Multi-Components Aqueous Solution by Natural Clinoptilolite. J Hazard Mater. 2010 Aug 15;180(1-3):282-8.
Cabanero AI, Madrid Y, Camara C. Effect of Animal Feed Enriched with Se and Clays on Hg Bioaccumulation in Chickens: in vivo Experimental Study. J Agric Food Chem. 2005 Mar 23;(53(6):2125-32.
Hou Y, Wu P, Zhu N. The Protective Effect of Clay Minerals Against Damage to Adsorbed DNA Induced by Cadmium and Mercury. Chemosphere. 2014 Jan;95:206-12.
Mier MV, Callejas RL, Gehr R, Cisneros BEJ. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Component Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
Haidouti C. Inactivation of mercury in contaminated soils using natural zeolites. Sci Total Environ. 1997 Dec 3;208(1-2):105-9.
Bilgin Simsek E, Avci Tuna AO, Beker U. A Statistical Approach for Arsenic Adsorption onto Turkey Clinoptilolite. Environ Sci Pollut Res Int. 2015 Mar;22(5):3249-56.
Payne KB, Abdel-Fattah TM. Adsorption of Arsenate and Arsenite by Iron-Treated Activated Carbon and Zeolites: Effects of pH, Temperature, and Ionic Strength. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2005;40(4):723-49.
Delavarian M, Hassanvand A, Gharibzadeh S. Increasing Performance in Children with ADHD by Trapping Lead with a Nano-Zeolite. J Neuropsychiat Clin Neurosci. 2013;25(1):E23.
Orhan Y, Kocaoba S. Adsorption of Toxic Metals by Natural and Modified Clinoptilolite. Ann Chim. 2007 Aug;97(8):781-90.
Vaca Mier M, et al. Heavy Metal Removal with Mexican Clinoptilolite: Multi-Componnent Ionic Exchange. Water Res. 2001 Feb;35(2):373-8.
Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
Pond WG, Yen JT. Protection by Clinoptilolite or Zeolite NaA Against Cadmium-Induced Anemia in Growing Swine. Proc Soc Exp Biol Med. 1983 Jul;173(3):332-7.
Castalki P, Santona L, Enzo S, Melis P. Sorption Processes and XRD Analysis of a Natural Zeolite Exchange with Pb(2+), Cd(2+) and Zn(2+) Cations. J Hazard Mater. 2008 Aug 15;156(1-3)428-34.
Chi SL, et al. [Effect of Nano Zeolites on pH, CEC in Soil and Cd Fractions in Plant and Soil at Different Cadmium Levels]. Huan Jing Ke Xeu. 2017 Apr 8;38(4):1654-66.
Sprynskyy M, Buszewski B, Terzyk AP, Namiesnik J. Study of the Selection Mechanism of Heavy Metal (Pb2+, Cu2+, Ni2+, and Cd2+) Adsorption on Clinoptilolite. J Colliod Interface Sci. 2006 Dec 1;304(1):21-8.
Forberg S, Jones B, Westermark T. Can zeolites decrease the uptake and accelerate the excretion of radio-caesium in ruminants? Sci. Total Environ. 1989;79:37–41.
Mitrovic BM, et al. Comparative Study of (137)Cs Distribution in Broilers and Pheasants and Possibilities for Protection. Radiat Environ Biophys. 2012 Mar;51(1):79-84.
Mitrovic B, et al. AFCF and Clinoptilolite Use in Reduction of (137)Cs Deposition in Several Days’ Contamination Broiler Chicks. J Environ Radioact. 2007;95(2-3):171-7.
Schofield K. The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics? Int J Environ Res Public Health. 2017 Dec 5;14(12). pii. E1511.
Faghir H, Hassanvand A, Gharibzadeh S. Removing Cadmium by Nano-Pore Zeolites to Decrease Aggressive Behavior, Stress, and Hyperactivity. J Neuropsychiat Clin Neurosci. 2013;25(2):E73.
Montinaro M, et al. Life Sci. 2013 May 20;92(17-19):903-10.
Dogliotti G, et al. Natural Zeolites Chabazite/Phillipsite/Analcime Increase Blood Levels of Antioxidants. J Clin Biochem Nutr. 2012 May;50(3):195-8.
Choi J, et al. Mercury Exposure in Association with Decreased of Liver Function in Adjults: A Longitudinal Study. J Prev Med Public Health. 2017 Nov;50(6):377-85.
Cheinia HY, Jacobs A. Dis Aquat Organ. 2017 Nov 21;126(3):199-209.
Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota and Reduces Campylobacter Load. PLoS One 2016 Apr 26;11(4):e0154061.
Bonna RJ, et al. Efficacy of Hydrated Sodium Calcium Aluminosilicate and Activated Charcoal in Reducing the Toxicity of Dietary Aflatoxin to Mink. Arch Environ Cotamin Toxicol. 1991 Apr;20(3):441-7.
Jung BG, et al. Vet Microbiol. 2010 Jul 14;143(2-4):117-25.
Sabbioni A, et al. Modulation of the Bifidobacterial Communities of the Dog Microbiota by Zeolite. Front Microbiol. 2016;7:1491.
Song M, et al. Dietary Clays Alleviate Diarrhea of Weaned Pigs. J Anim Sci. 2012 Jan;90(1):345-60.
Subramaniam MD, Kim IH. Clays as Dietary Supplements for Swine: A Review. J Anim Sci Biotechnol. 2015 Aug 22;6(1):38.
Almeida JA, et al. Poult Sci. 2014 Apr;93(4):839-47.
Prasai TP, et al. Biochar, Bentonite and Zeolite Supplemented Feeding of Layer Chickens Alters Intestinal Microbiota.... PLoS One. 2016 Apr 26;11(4):e0154061.
Papaioannou D., Katsoulos P. D., Panousis N., Karatzias H. The role of natural and synthetic zeolites as feed additives.... Microporous Mesoporous Mater. 2005;84:161–70.
RodriguezFuentes G, Barrios MA, Iraizoz A, Perdomo I, Cedre B. Zeolites 1997;19:441–8.
Zarcovic N, et al. Anticancer Res. 2003;23:1589–96.
Pavelic K, et al. Immunostimulatory effect of natural clinoptilolite.... J Cancer Res Clin Oncol. 2002 Jan; 128(1):37-44.
Muck-Seler D, Pivac N. The Effect of Natural Clinoptilolite on the Serotonergic Receptors in the Brain of Mice... Life Sci. 2003 Sep 5;73(16):2059-69.
Subramaniam MD, Kim IH. Clays as Dietary Supplements for Swine: A Review. J Anim Sci Biotechnol. 2015 Aug 22;6(1):38.
Wu QJ, Zhou YM, Wu YN, Zhang LL, Wang T. The Effects of Natural and Modified Clinoptilolite on Intestinal Barrier Functions and Immune Response to LPS in Broiler Chickens. Vet Immunol Immunopathol. 2013 May 15;153(1-2):70-6.
Visnja S, Sandra S, Tihomir B, Miroslav C, Tatjana M. Natural micronised clinoptilolite and clinoptilolite mixtures with Urtica dioicaL. extract as possible antioxidants. Food Technol Biotechnol. 2004;42(3):189–92.
Ortatatli M, Oguz H, Hatipoglu F, Karaman M. Evaluation of Pathological Changes in Broilers During Chronic Aflatoxin (50 and 100 ppb) and Clinoptilolite Exposure. Res Vet Sci. 2005 Feb;78(1):61-8.
Selvam T, Schwieger W, Dathe W. Histamine-Binding Capacities of Different Natural Zeolite: A Comparative Study. Environ Geochem Health. 2018 Jun 7. Doi: 10.1007/s10653-018-0129-5.
Ivkovic S, et al. Dietary Supplementation with the Tribomechanically Activated Zeolite Clinoptilolite in Immunodeficiency: Effects on the Immune System. Adv Ther. 2004 Mar-Apr;21(2):135-47.
Pavelic K, et al. Immunostimulatory Effect of Natural Zeolite Clinoptilolite.... J Cancer Res Clin Oncol. 2002 Jan;128(1):37-44.
Fach E, et al. Analysis of the Biological and Chemical Reactivity of Zeolite-Based Aluminosilicate Fibers and Particlues. Environ Health Perspect. 2002 Nov;110(11):1087-96.
Laurino C, Palmieri B. Zeolite: “The Magic Stone”; Main Nutritional, Environmental, Experimental and Clinical Fields of Application. Nutr Hosp. 2015 Aug 1;32(2):573-81.
Wu Y, Wu Q, Zhou Y, Ahmad H, Wang T. Effects of Clinoptilolite on Growth Performance and Antioxidant Status in Broilers. Biol Trace Elem Res. 2013;155(2):228-35.
Omidi H, et al. Effects of Separate and Concurrent Supplementation of Nano-Sized Clinoptilolite and Nigella sativa on Oxidative Stress, Anti-oxidative Parameters and Body Weight in Rats with Type 2 Diabetes. Biomed Pharmacother. 2017 Dec;96:1335-40.
Shurson GC, Ku PK, Miller ER, Yokoyama MT. Effects of Zeolite A or Clinoptilolite in Diets of Growing Swine. J Anim Sci. 1984 Dec;59(6):1536-45.
Maisanaba S, et al. Toxicological Evaluation of Clay Minerals and Derived Nanocomposites: A Review. Environ Res. 2015 Apr;138:233-54.
Ivkovic S, et al. Dietary Supplementation with the Tribomechanically Activated Zeolite Clinoptilolite in Immunodeficiency: Effects on the Immune System. Adv Ther. 2004 Mar-Apr;21(2):135-47.
Selvam T, Schwieger W, Dathe W. Histamine-Binding Capacities of Different Natural Zeolite: A Comparative Study. Environ Geochem Health. 2018 Jun 7. Doi: 10.1007/s10653-018-0129-5.
Dogliotti G, et al. Natural Zeolites Chabazite/Phillipsite/Analcime Increase Blood Levels of Antioxidants. J Clin Biochem Nutr. 2012 May;50(3):195-8.